MC8: Applications of Accelerators, Technology Transfer, Industrial Relations and Outreach
U01 Medical Applications
Paper Title Page
THVIR12 FLASH Radiation Therapy: Accelerator Aspects 71
 
  • A. Patriarca, L. De Marzi, V. Favaudon, S.J. Meyroneinc
    Institut Curie - Centre de Protonthérapie d’Orsay, Orsay, France
 
  One of the new paradigms in radiation therapy (RT) is the FLASH dose delivery irradiation technique. The FLASH methodology consists in delivering millisecond pulses of radiation (total beam-on time < 100-500 ms) delivered at a high mean dose-rate (> 40-100 Gy/s) and pulse amplitude (> 1E6 Gy/s), over 2000 times faster than in conventional RT. New accelerator ideas are under development or are being tested to deliver this type of beam. In this paper we will report the accelerator technology used for the pre-clinical studies and the necessary developments to deliver this novel dose RT technique.  
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DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2020-THVIR12  
About • paper received ※ 01 June 2020       paper accepted ※ 12 June 2020       issue date ※ 28 September 2020  
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THVIR13 CERN-MEDICIS: A Unique Facility for the Production of Non-Conventional Radionuclides for the Medical Research 75
 
  • C. Duchemin, E. Barbero-Soto, A.P. Bernardes, R. Catherall, E. Chevallay, A. Dorsival, V.N. Fedosseev, P. Fernier, S.S. Gilardoni, J.L. Grenard, L. Lambert, G. Lilli, G. Lilli, G. Lunghi, B.A. Marsh, Y. Martinez Palenzuela, S. Marzari, F. Pozzi, J. Riegert, S. Rothe, T. Stora, J. Vollaire, N.-T. Vuong, S. Wilkins
    CERN, Meyrin, Switzerland
  • T.E. Cocolios, R. Heinke
    KU Leuven, Leuven, Belgium
  • F. Haddad
    Cyclotron ARRONAX, Saint-Herblain, France
  • M.A. Khan
    PINSTECH, Islamabad, Pakistan
  • N. Michel
    SUBATECH, Nantes, France
  • J.P. Ramos
    SCK•CEN, Mol, Belgium
  • Z. Talip, N.P. van der Meulen
    PSI, Villigen PSI, Switzerland
  • K. Wendt
    Johannes Gutenberg University Mainz, Institut für Physik, Mainz, Germany
  • K. Wendt
    Mainz University, Mainz, Germany
 
  The MEDICIS facility is a unique facility located at CERN dedicated to the production of non-conventional radionuclides for research and development in imaging, diagnostics and radiation therapy. It exploits in a Class A work sector, a dedicated isotope separator beam line, a target irradiation station at the 1.4 GeV Proton Synchroton Booster (PSB) and receives activated targets from external institutes during CERN Long Shut-Downs. The target is heated up at high temperatures to allow for the diffusion and effusion of the atoms out of the target that are subsequently ionized. The ions are accelerated and sent through an off-line mass separator. The radionuclide of interest is extracted through mass separation and implanted into a thin metallic collection foil. After collection, the batch is prepared to be dispatched to a research center. In the near-future, the radiochemistry process will also be performed in MEDICIS. Since its commissioning in December 2017, the facility has provided novel radionuclides such as Tb-149, Tb-155, Tm-165, Er-169 and Yb-175 with high specific activity, some for the first time, to European research institutes part of the collaboration.  
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DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-IPAC2020-THVIR13  
About • paper received ※ 09 June 2020       paper accepted ※ 12 June 2020       issue date ※ 23 September 2020  
Export • reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)